ML1808 is an intranasal anti-dementia drug.
It suppresses not only Aβ oligomer but also tau oligomer and oxidative stress by using 2 active ingredients: rifampicin(RFP) and compound X.
Intranasal rifampicin for Alzheimer’s disease prevention
Alzheimer’s & Dementia: Translational Research & Clinical Interventions 4 (2018) 304-313
Alz & Dement Transl Res Clin Interv2018
Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers
BRAIN (2016) 139; 1568-1586
Rifampicin inhibis the toxicity of pre-aggregated amyloid peptides by binding to peptide fibrils and preventing amyloid-cell interaction
Biochem. J. (1997) 322, 859-865
Biochem J 1997
Inhibition of Amyloid β Protein Aggregation and Neurotoxicity by Rifampicin
Journal of Biological Chemistry, Vol. 271, No. 12, Issue of March 22 (1996) 6839-6844
J Biol Chem 1996
Rifampicin prevents the aggregation and Neurotoxicity of amyloid β protein in vitro
Biochemical and Biophysical Research Communications, vol. 204, No. 1 (1994) 76-83